🔬 AMP Candidates
2,065 computationally predicted antimicrobial peptide candidates
🧬 About these candidates
Each candidate was identified by mining extreme-environment metagenomes with ESM-2, a protein language model trained on 250M sequences. Candidates pass multi-stage filtering: biophysical scoring, novelty screening against 863K known AMPs (APD3 + DRAMP + AMPSphere), hemolysis risk prediction, and structural validation via AlphaFold2.
⚠️ All candidates are computationally predicted — no experimental validation has been performed.
🔒Amino acid sequences are not shown — sequences are proprietary research data. Interested in collaboration? Contact us.
🌋
#1369
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9253
LengthPeptide length in amino acids46 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)59%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.73)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1370
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9253
LengthPeptide length in amino acids35 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.62)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1371
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9252
LengthPeptide length in amino acids27 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)33%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.31)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1372
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9252
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)42%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.21)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1373
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9249
LengthPeptide length in amino acids31 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)55%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.47)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1374
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9249
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.5
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.19)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1375
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9248
LengthPeptide length in amino acids48 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1376
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9247
LengthPeptide length in amino acids33 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.5
HydrophobicFraction of hydrophobic residues (0–1)58%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.50)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1377
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9247
LengthPeptide length in amino acids37 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.71)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1378
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9247
LengthPeptide length in amino acids25 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)32%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.27)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1379
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids32 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)41%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.30)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1380
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.44)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1381
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.44)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1382
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids28 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)14%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1383
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids28 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)14%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1384
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids25 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.26)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1385
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids39 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)54%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.33)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1386
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9246
LengthPeptide length in amino acids37 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)49%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.46)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1387
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9244
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.29)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1388
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9244
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)56%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.61)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1389
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9244
LengthPeptide length in amino acids42 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.36)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1390
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9243
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.5
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.68)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1391
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9242
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)54%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.69)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1392
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9242
LengthPeptide length in amino acids20 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)35%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.19)
0% max identityHighest sequence identity to any known AMP in databases
📚 Understanding the metrics
ESM-2 AMP Score: Probability (0–1) that the peptide has antimicrobial activity, predicted by Meta's ESM-2 protein language model.
Net Charge: Charge at physiological pH. Most effective AMPs carry a positive charge (+2 to +9).
Hemolysis Prob: SVM-predicted probability of red blood cell lysis (HemoPi3). Below 0.5 is considered non-hemolytic.
Novelty Tier: How similar to known AMPs. "database-novel" means <50% identity to any AMP in APD3 + DRAMP + AMPSphere.
Hydrophobic fraction: Proportion of hydrophobic amino acids. AMPs typically have 40–60% for membrane interaction.
Cross-biome: Found independently in multiple extreme environments — suggests evolutionary conservation of antimicrobial function.