🔬 AMP Candidates
2,065 computationally predicted antimicrobial peptide candidates
🧬 About these candidates
Each candidate was identified by mining extreme-environment metagenomes with ESM-2, a protein language model trained on 250M sequences. Candidates pass multi-stage filtering: biophysical scoring, novelty screening against 863K known AMPs (APD3 + DRAMP + AMPSphere), hemolysis risk prediction, and structural validation via AlphaFold2.
⚠️ All candidates are computationally predicted — no experimental validation has been performed.
🔒Amino acid sequences are not shown — sequences are proprietary research data. Interested in collaboration? Contact us.
🌋
#1537
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9118
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.5
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.50)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1538
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9116
LengthPeptide length in amino acids50 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.5
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.18)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1539
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9114
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)42%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.18)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1540
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9112
LengthPeptide length in amino acids27 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.5
HydrophobicFraction of hydrophobic residues (0–1)30%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.37)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1541
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9112
LengthPeptide length in amino acids33 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.52)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1542
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9111
LengthPeptide length in amino acids34 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)53%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.54)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1543
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9111
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)41%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.49)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1544
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9110
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)29%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.28)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1545
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9110
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)29%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.28)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1546
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9110
LengthPeptide length in amino acids29 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)34%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.25)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1547
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9109
LengthPeptide length in amino acids50 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.32)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1548
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9109
LengthPeptide length in amino acids38 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.5
HydrophobicFraction of hydrophobic residues (0–1)37%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.12)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1549
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9109
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)49%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.57)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1550
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9108
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)47%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.74)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1551
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9106
LengthPeptide length in amino acids48 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)10.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.74)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1552
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9106
LengthPeptide length in amino acids48 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)10.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.74)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1553
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9106
LengthPeptide length in amino acids50 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)38%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.32)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1554
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9105
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)41%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1555
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9102
LengthPeptide length in amino acids49 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.0
HydrophobicFraction of hydrophobic residues (0–1)43%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.27)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1556
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9100
LengthPeptide length in amino acids38 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)37%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1557
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9100
LengthPeptide length in amino acids31 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)35%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.60)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1558
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9100
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)55%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.79)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1559
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9098
LengthPeptide length in amino acids34 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)35%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.13)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1560
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9098
LengthPeptide length in amino acids48 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)23%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
📚 Understanding the metrics
ESM-2 AMP Score: Probability (0–1) that the peptide has antimicrobial activity, predicted by Meta's ESM-2 protein language model.
Net Charge: Charge at physiological pH. Most effective AMPs carry a positive charge (+2 to +9).
Hemolysis Prob: SVM-predicted probability of red blood cell lysis (HemoPi3). Below 0.5 is considered non-hemolytic.
Novelty Tier: How similar to known AMPs. "database-novel" means <50% identity to any AMP in APD3 + DRAMP + AMPSphere.
Hydrophobic fraction: Proportion of hydrophobic amino acids. AMPs typically have 40–60% for membrane interaction.
Cross-biome: Found independently in multiple extreme environments — suggests evolutionary conservation of antimicrobial function.