🔬 AMP Candidates
2,713 computationally predicted antimicrobial peptide candidates
🧬 About these candidates
Each candidate was identified by mining extreme-environment metagenomes with ESM-2, a protein language model trained on 250M sequences. Candidates pass multi-stage filtering: biophysical scoring, novelty screening against 863K known AMPs (APD3 + DRAMP + AMPSphere), hemolysis risk prediction, and structural validation via AlphaFold2.
⚠️ All candidates are computationally predicted — no experimental validation has been performed.
🔒Amino acid sequences are not shown — sequences are proprietary research data. Interested in collaboration? Contact us.
🌋
#1105
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9604
LengthPeptide length in amino acids48 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.5
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.39)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1106
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9602
LengthPeptide length in amino acids43 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.5
HydrophobicFraction of hydrophobic residues (0–1)37%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.12)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1107
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9602
LengthPeptide length in amino acids27 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.62)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1108
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9602
LengthPeptide length in amino acids32 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.33)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1109
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9602
LengthPeptide length in amino acids46 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)43%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.31)
ToxinToxinPred2 toxicity prediction(0.62)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1110
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9602
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.5
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.21)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1111
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9601
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.5
HydrophobicFraction of hydrophobic residues (0–1)39%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.64)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1112
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9601
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.5
HydrophobicFraction of hydrophobic residues (0–1)39%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.64)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1113
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9601
LengthPeptide length in amino acids23 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)30%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.24)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1114
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9600
LengthPeptide length in amino acids43 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)56%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.36)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1115
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9600
LengthPeptide length in amino acids48 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)35%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.24)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1116
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9599
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.61)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1117
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9599
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.59)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1118
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9598
LengthPeptide length in amino acids28 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)32%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.09)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1119
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9598
LengthPeptide length in amino acids30 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)47%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.62)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1120
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9597
LengthPeptide length in amino acids39 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)11.0
HydrophobicFraction of hydrophobic residues (0–1)41%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.30)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1121
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9595
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.5
HydrophobicFraction of hydrophobic residues (0–1)54%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.73)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1122
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9595
LengthPeptide length in amino acids20 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)55%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.44)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1123
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9595
LengthPeptide length in amino acids20 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)55%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.44)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1124
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9595
LengthPeptide length in amino acids33 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)52%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.39)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1125
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9594
LengthPeptide length in amino acids28 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.62)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1126
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9594
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)51%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.19)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1127
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9594
LengthPeptide length in amino acids46 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)39%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.46)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1128
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9593
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.85)
0% max identityHighest sequence identity to any known AMP in databases
📚 Understanding the metrics
ESM-2 AMP Score: Probability (0–1) that the peptide has antimicrobial activity, predicted by Meta's ESM-2 protein language model.
Net Charge: Charge at physiological pH. Most effective AMPs carry a positive charge (+2 to +9).
Hemolysis Prob: SVM-predicted probability of red blood cell lysis (HemoPi3). Below 0.5 is considered non-hemolytic.
Novelty Tier: How similar to known AMPs. "database-novel" means <50% identity to any AMP in APD3 + DRAMP + AMPSphere.
Hydrophobic fraction: Proportion of hydrophobic amino acids. AMPs typically have 40–60% for membrane interaction.
Cross-biome: Found independently in multiple extreme environments — suggests evolutionary conservation of antimicrobial function.