🔬 AMP Candidates
2,713 computationally predicted antimicrobial peptide candidates
🧬 About these candidates
Each candidate was identified by mining extreme-environment metagenomes with ESM-2, a protein language model trained on 250M sequences. Candidates pass multi-stage filtering: biophysical scoring, novelty screening against 863K known AMPs (APD3 + DRAMP + AMPSphere), hemolysis risk prediction, and structural validation via AlphaFold2.
⚠️ All candidates are computationally predicted — no experimental validation has been performed.
🔒Amino acid sequences are not shown — sequences are proprietary research data. Interested in collaboration? Contact us.
🌋
#1585
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9359
LengthPeptide length in amino acids32 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)38%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.17)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1586
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9359
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score5.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.51)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1587
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9359
LengthPeptide length in amino acids48 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.5
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.22)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1588
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9359
LengthPeptide length in amino acids21 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)52%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.20)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1589
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9358
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)14.0
HydrophobicFraction of hydrophobic residues (0–1)17%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.36)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1590
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9357
LengthPeptide length in amino acids38 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)39%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.13)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1591
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9357
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)47%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.44)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1592
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9357
LengthPeptide length in amino acids50 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.5
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.55)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1593
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9357
LengthPeptide length in amino acids42 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)10.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.22)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1594
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9354
LengthPeptide length in amino acids25 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)11.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.30)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1595
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9354
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)43%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.55)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1596
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9354
LengthPeptide length in amino acids40 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.72)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1597
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9354
LengthPeptide length in amino acids33 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)9.0
HydrophobicFraction of hydrophobic residues (0–1)36%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.09)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1598
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9353
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.5
HydrophobicFraction of hydrophobic residues (0–1)41%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.47)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1599
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9351
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.43)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1600
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9351
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.43)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1601
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9351
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.50)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1602
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9350
LengthPeptide length in amino acids36 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.44)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1603
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9350
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)62%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.72)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1604
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9349
LengthPeptide length in amino acids23 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)57%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.84)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1605
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9349
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)9.5
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.40)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1606
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9347
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.5
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.38)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1607
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9347
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.5
HydrophobicFraction of hydrophobic residues (0–1)45%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.38)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1608
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9347
LengthPeptide length in amino acids29 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.5
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.65)
0% max identityHighest sequence identity to any known AMP in databases
📚 Understanding the metrics
ESM-2 AMP Score: Probability (0–1) that the peptide has antimicrobial activity, predicted by Meta's ESM-2 protein language model.
Net Charge: Charge at physiological pH. Most effective AMPs carry a positive charge (+2 to +9).
Hemolysis Prob: SVM-predicted probability of red blood cell lysis (HemoPi3). Below 0.5 is considered non-hemolytic.
Novelty Tier: How similar to known AMPs. "database-novel" means <50% identity to any AMP in APD3 + DRAMP + AMPSphere.
Hydrophobic fraction: Proportion of hydrophobic amino acids. AMPs typically have 40–60% for membrane interaction.
Cross-biome: Found independently in multiple extreme environments — suggests evolutionary conservation of antimicrobial function.