🔬 AMP Candidates
2,713 computationally predicted antimicrobial peptide candidates
🧬 About these candidates
Each candidate was identified by mining extreme-environment metagenomes with ESM-2, a protein language model trained on 250M sequences. Candidates pass multi-stage filtering: biophysical scoring, novelty screening against 863K known AMPs (APD3 + DRAMP + AMPSphere), hemolysis risk prediction, and structural validation via AlphaFold2.
⚠️ All candidates are computationally predicted — no experimental validation has been performed.
🔒Amino acid sequences are not shown — sequences are proprietary research data. Interested in collaboration? Contact us.
🌋
#1705
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9294
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)51%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.65)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1706
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9294
LengthPeptide length in amino acids46 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.5
HydrophobicFraction of hydrophobic residues (0–1)33%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.13)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1707
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9293
LengthPeptide length in amino acids32 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)15.0
HydrophobicFraction of hydrophobic residues (0–1)16%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.06)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1708
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9293
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.10)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1709
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9293
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)40%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.10)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1710
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9293
LengthPeptide length in amino acids28 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.48)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1711
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9291
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)25%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.28)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1712
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9291
LengthPeptide length in amino acids24 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)25%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.28)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1713
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9290
LengthPeptide length in amino acids32 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)53%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.21)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1714
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9289
LengthPeptide length in amino acids50 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.38)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1715
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9289
LengthPeptide length in amino acids50 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.38)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1716
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9289
LengthPeptide length in amino acids21 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)62%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.92)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1717
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9288
LengthPeptide length in amino acids44 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)14.5
HydrophobicFraction of hydrophobic residues (0–1)32%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.10)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1718
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9288
LengthPeptide length in amino acids28 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.5
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1719
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9288
LengthPeptide length in amino acids30 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)50%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.59)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1720
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9287
LengthPeptide length in amino acids43 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)51%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.39)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1721
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9286
LengthPeptide length in amino acids38 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)9.5
HydrophobicFraction of hydrophobic residues (0–1)55%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.78)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1722
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9286
LengthPeptide length in amino acids38 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)9.5
HydrophobicFraction of hydrophobic residues (0–1)55%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.78)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1723
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9286
LengthPeptide length in amino acids35 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)31%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
ToxinToxinPred2 toxicity prediction(0.75)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1724
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9286
LengthPeptide length in amino acids36 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)64%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.28)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1725
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9285
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)42%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.07)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1726
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9285
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)12.0
HydrophobicFraction of hydrophobic residues (0–1)41%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.25)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#1727
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9285
LengthPeptide length in amino acids27 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.35)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#1728
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9284
LengthPeptide length in amino acids46 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.64)
0% max identityHighest sequence identity to any known AMP in databases
📚 Understanding the metrics
ESM-2 AMP Score: Probability (0–1) that the peptide has antimicrobial activity, predicted by Meta's ESM-2 protein language model.
Net Charge: Charge at physiological pH. Most effective AMPs carry a positive charge (+2 to +9).
Hemolysis Prob: SVM-predicted probability of red blood cell lysis (HemoPi3). Below 0.5 is considered non-hemolytic.
Novelty Tier: How similar to known AMPs. "database-novel" means <50% identity to any AMP in APD3 + DRAMP + AMPSphere.
Hydrophobic fraction: Proportion of hydrophobic amino acids. AMPs typically have 40–60% for membrane interaction.
Cross-biome: Found independently in multiple extreme environments — suggests evolutionary conservation of antimicrobial function.