🔬 AMP Candidates
2,713 computationally predicted antimicrobial peptide candidates
🧬 About these candidates
Each candidate was identified by mining extreme-environment metagenomes with ESM-2, a protein language model trained on 250M sequences. Candidates pass multi-stage filtering: biophysical scoring, novelty screening against 863K known AMPs (APD3 + DRAMP + AMPSphere), hemolysis risk prediction, and structural validation via AlphaFold2.
⚠️ All candidates are computationally predicted — no experimental validation has been performed.
🔒Amino acid sequences are not shown — sequences are proprietary research data. Interested in collaboration? Contact us.
🌋
#193
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9962
LengthPeptide length in amino acids30 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)7.0
HydrophobicFraction of hydrophobic residues (0–1)53%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.23)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#194
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9962
LengthPeptide length in amino acids23 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.52)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#195
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9961
LengthPeptide length in amino acids43 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.0
HydrophobicFraction of hydrophobic residues (0–1)53%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.45)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#196
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9960
LengthPeptide length in amino acids39 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.0
HydrophobicFraction of hydrophobic residues (0–1)49%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.83)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#197
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9960
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)11.0
HydrophobicFraction of hydrophobic residues (0–1)28%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.40)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#198
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9960
LengthPeptide length in amino acids23 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.40)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#199
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9959
LengthPeptide length in amino acids37 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.0
HydrophobicFraction of hydrophobic residues (0–1)57%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.72)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#200
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9959
LengthPeptide length in amino acids30 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.5
HydrophobicFraction of hydrophobic residues (0–1)57%
PhyschemComposite physicochemical plausibility score4.0
⚠️ Hemolysis riskPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.79)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#201
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9958
LengthPeptide length in amino acids35 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)23.5
HydrophobicFraction of hydrophobic residues (0–1)17%
PhyschemComposite physicochemical plausibility score3.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.03)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#202
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9958
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)6.0
HydrophobicFraction of hydrophobic residues (0–1)46%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.12)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#203
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9958
LengthPeptide length in amino acids31 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)39%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.37)
0% max identityHighest sequence identity to any known AMP in databases
🧊
#204
🧊 Permafrost
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9958
LengthPeptide length in amino acids31 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)39%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.37)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#205
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids34 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)2.5
HydrophobicFraction of hydrophobic residues (0–1)35%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.12)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#206
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids49 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)4.5
HydrophobicFraction of hydrophobic residues (0–1)37%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.29)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#207
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids47 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.5
HydrophobicFraction of hydrophobic residues (0–1)51%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.24)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#208
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)49%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.49)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#209
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)5.0
HydrophobicFraction of hydrophobic residues (0–1)49%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.49)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#210
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids34 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)65%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.31)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#211
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids34 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.5
HydrophobicFraction of hydrophobic residues (0–1)65%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.31)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#212
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9957
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)12.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.47)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#213
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9956
LengthPeptide length in amino acids45 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)36%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.18)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#214
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9956
LengthPeptide length in amino acids41 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)3.0
HydrophobicFraction of hydrophobic residues (0–1)44%
PhyschemComposite physicochemical plausibility score4.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.14)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#215
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9956
LengthPeptide length in amino acids31 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.0
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.16)
0% max identityHighest sequence identity to any known AMP in databases
🌋
#216
🌋 Hot Springs
database-novel
ESM-2 AMP ScoreProbability of antimicrobial activity (0–1). Higher = more likely AMP.
0.9956
LengthPeptide length in amino acids31 aa
Net ChargeCharge at pH 7. Most AMPs are cationic (+)8.0
HydrophobicFraction of hydrophobic residues (0–1)48%
PhyschemComposite physicochemical plausibility score5.0
✅ Low hemolysisPredicted probability of red blood cell lysis. <0.5 = non-hemolytic(0.16)
0% max identityHighest sequence identity to any known AMP in databases
📚 Understanding the metrics
ESM-2 AMP Score: Probability (0–1) that the peptide has antimicrobial activity, predicted by Meta's ESM-2 protein language model.
Net Charge: Charge at physiological pH. Most effective AMPs carry a positive charge (+2 to +9).
Hemolysis Prob: SVM-predicted probability of red blood cell lysis (HemoPi3). Below 0.5 is considered non-hemolytic.
Novelty Tier: How similar to known AMPs. "database-novel" means <50% identity to any AMP in APD3 + DRAMP + AMPSphere.
Hydrophobic fraction: Proportion of hydrophobic amino acids. AMPs typically have 40–60% for membrane interaction.
Cross-biome: Found independently in multiple extreme environments — suggests evolutionary conservation of antimicrobial function.